2 answers
Thomas’s Answer
1) First, focus on the characters. It doesn't matter if it's science fiction, fantasy, historical fiction, or something in the modern day--the story is about the characters, the conflicts they encounter, and how they resolve them. Stay away from black and white, good vs evil characters, too. They will be more interesting in shades of gray.
2) Make sure the plot is solid. The setting alone, even if it's a sci-fi world, won't carry the whole novel. I have read work by people in my writing group where the concept is amazing, based on really unique ideas, but the plot goes nowhere, or is too predictable.
3) Then, focus on your world building. Watch out for too much exposition, though, which can be common in sci-fi because you want to tell us all about the world you've created. We don't want to read what feels like an encyclopedia entry, though. Give it to us little by little, as part of the narrative. Show, don't tell.
In essence, regardless of the genre, the main pieces that make up a good novel need to be there, and if your sci-fi world is super weird, knowledge of how it works needs to be disseminated in a way that doesn't turn the reader off. Keep us wanting more without overwhelming us with technobabble.
Then, to make it unique, subvert our expectations with plot twists that make sense within the rules of the world you've created, which will still likely come down to the decisions of characters pursuing their goals.
E. C’s Answer
Maurice W,
Follow these instructions and you shall be fine.
E. C recommends the following next steps: